Ontology highlight
ABSTRACT:
SUBMITTER: Duque MD
PROVIDER: S-EPMC3174104 | biostudies-literature | 2011 Apr
REPOSITORIES: biostudies-literature
Journal of medicinal chemistry 20110405 8
Amantadine inhibits the M2 proton channel of influenza A virus, yet its clinical use has been limited by the rapid emergence of amantadine-resistant virus strains. We have synthesized and characterized a series of polycyclic compounds designed as ring-contracted or ring-expanded analogues of amantadine. Inhibition of the wild-type (wt) M2 channel and the A/M2-S31N and A/M2-V27A mutant ion channels were measured in Xenopus oocytes using two-electrode voltage clamp (TEV) assays. Several bisnoradam ...[more]