Ontology highlight
ABSTRACT:
SUBMITTER: Kao H
PROVIDER: S-EPMC2857686 | biostudies-literature | 2008 Dec
REPOSITORIES: biostudies-literature
Kao Henry H Lin Joseph J Littman Dan R DR Shaw Andrey S AS Allen Paul M PM
Journal of immunology (Baltimore, Md. : 1950) 20081201 12
The mechanism underlying the transient accumulation of CD4 at the immunological synapse (IS) and its significance for T cell activation are not understood. To investigate these issues, we mutated a serine phosphorylation site (S408) in the cytoplasmic tail of murine CD4. Preventing phosphorylation of S408 did not block CD4 recruitment to the IS; rather, it blocked the ability of CD4 to leave the IS. Surprisingly, enhanced and prolonged CD4 accumulation at the supramolecular activation cluster in ...[more]