Ontology highlight
ABSTRACT:
SUBMITTER: Combs J
PROVIDER: S-EPMC1595445 | biostudies-literature | 2006 Oct
REPOSITORIES: biostudies-literature
Combs Jeffrey J Kim Soo Jin SJ Tan Sarah S Ligon Lee A LA Holzbaur Erika L F EL Kuhn Jeffrey J Poenie Martin M
Proceedings of the National Academy of Sciences of the United States of America 20060921 40
Binding of T cells to antigen-presenting cells leads to the formation of the immunological synapse, translocation of the microtubule-organizing center (MTOC) to the synapse, and focused secretion of effector molecules. Here, we show that upon activation of Jurkat cells microtubules project from the MTOC to a ring of the scaffolding protein ADAP, localized at the synapse. Loss of ADAP, but not lymphocyte function-associated antigen 1, leads to a severe defect in MTOC polarization at the immunolog ...[more]