Ontology highlight
ABSTRACT:
SUBMITTER: Honda M
PROVIDER: S-EPMC2858449 | biostudies-literature | 2009 Aug
REPOSITORIES: biostudies-literature
Honda Mitsuo M Wang Rui R Kong Wing-Pui WP Kanekiyo Masaru M Akahata Wataru W Xu Ling L Matsuo Kazuhiro K Natarajan Kannan K Robinson Howard H Asher Tedi E TE Price David A DA Douek Daniel C DC Margulies David H DH Nabel Gary J GJ
Journal of immunology (Baltimore, Md. : 1950) 20090720 4
Prime-boost immunization with gene-based vectors has been developed to generate more effective vaccines for AIDS, malaria, and tuberculosis. Although these vectors elicit potent T cell responses, the mechanisms by which they stimulate immunity are not well understood. In this study, we show that immunization by a single gene product, HIV-1 envelope, with alternative vector combinations elicits CD8(+) cells with different fine specificities and kinetics of mobilization. Vaccine-induced CD8(+) T c ...[more]