Activation of estrogen-responsive genes does not require their nuclear co-localization.
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ABSTRACT:
SUBMITTER: Kocanova S
PROVIDER: S-EPMC2858706 | biostudies-literature | 2010 Apr
REPOSITORIES: biostudies-literature
Publications
Activation of estrogen-responsive genes does not require their nuclear co-localization.
Kocanova Silvia S Kerr Elizabeth A EA Rafique Sehrish S Boyle Shelagh S Katz Elad E Caze-Subra Stephanie S Bickmore Wendy A WA Bystricky Kerstin K
PLoS genetics 20100422 4
The spatial organization of the genome in the nucleus plays a role in the regulation of gene expression. Whether co-regulated genes are subject to coordinated repositioning to a shared nuclear space is a matter of considerable interest and debate. We investigated the nuclear organization of estrogen receptor alpha (ERalpha) target genes in human breast epithelial and cancer cell lines, before and after transcriptional activation induced with estradiol. We find that, contrary to another report, t ...[more]
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