Ontology highlight
ABSTRACT:
SUBMITTER: Hearn A
PROVIDER: S-EPMC2858786 | biostudies-literature | 2010 May
REPOSITORIES: biostudies-literature
Hearn Arron A York Ian A IA Bishop Courtney C Rock Kenneth L KL
Journal of immunology (Baltimore, Md. : 1950) 20100329 9
Many MHC class I-binding peptides are generated as N-extended precursors during protein degradation by the proteasome. These peptides can subsequently be trimmed by aminopeptidases in the cytosol and/or the endoplasmic reticulum (ER) to produce mature epitope. However, the contribution and specificity of each of these subcellular compartments in removing N-terminal amino acids for Ag presentation is not well defined. In this study, we investigated this issue for antigenic precursors that are exp ...[more]