Ontology highlight
ABSTRACT:
SUBMITTER: Wang B
PROVIDER: S-EPMC3759077 | biostudies-literature | 2013
REPOSITORIES: biostudies-literature
Wang Bei B Niu Dandan D Lai Liyun L Ren Ee Chee EC
Nature communications 20130101
The p53 tumour suppressor has an important role in cancer cells. Here we show that p53 regulates expression of major histocompatibility complex I on the cell surface. We show that the tumour cell line HCT116, which lacks p53 exhibits significantly lower major histocompatibility complex I expression than its wild-type counterpart. Using a combination of chromatin immunoprecipitation sequencing and gene expression analysis, we demonstrate that p53 upregulates expression of endoplasmic reticulum am ...[more]