Ontology highlight
ABSTRACT:
SUBMITTER: Song L
PROVIDER: S-EPMC2859292 | biostudies-literature | 2006 Nov
REPOSITORIES: biostudies-literature
Song Lijiang L Barona-Gomez Francisco F Corre Christophe C Xiang Longkuan L Udwary Daniel W DW Austin Michael B MB Noel Joseph P JP Moore Bradley S BS Challis Gregory L GL
Journal of the American Chemical Society 20061101 46
Polyketide synthases (PKSs) are involved in the biosynthesis of many important natural products. In bacteria, type III PKSs typically catalyze iterative decarboxylation and condensation reactions of malonyl-CoA building blocks in the biosynthesis of polyhydroxyaromatic products. Here it is shown that Gcs, a type III PKS encoded by the sco7221 ORF of the bacterium Streptomyces coelicolor, is required for biosynthesis of the germicidin family of 3,6-dialkyl-4-hydroxypyran-2-one natural products. E ...[more]