Insights into ?-ketoacyl-chain recognition for ?-ketoacyl-ACP utilizing AHL synthases.
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ABSTRACT:
SUBMITTER: Nhu Lam M
PROVIDER: S-EPMC6124316 | biostudies-literature | 2018 Aug
REPOSITORIES: biostudies-literature
Publications
Insights into β-ketoacyl-chain recognition for β-ketoacyl-ACP utilizing AHL synthases.
Nhu Lam Mila M Dudekula Dastagiri D Durham Bri B Collingwood Noah N Brown Eric C EC Nagarajan Rajesh R
Chemical communications (Cambridge, England) 20180801 64
Beta-ketoacyl-ACP utilizing enzymes in fatty acid, polyketide and acyl-homoserine lactone biosynthetic pathways are important targets for developing antimicrobial, anticancer and antiparasitic compounds. Published reports on successful isolation of beta-ketoacyl-ACPs in a laboratory remain scarce to date and thus most beta-ketoacyl-ACP utilizing enzymes are routinely characterized using small molecule substrates in lieu of the bonafide 3-oxoacyl-ACPs. We report the systematic investigation into ...[more]
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