Ontology highlight
ABSTRACT:
SUBMITTER: Dickinson GD
PROVIDER: S-EPMC2859490 | biostudies-literature | 2010 Apr
REPOSITORIES: biostudies-literature
Dickinson George D GD Churchill Grant C GC Brailoiu Eugen E Patel Sandip S
The Journal of biological chemistry 20100315 18
Accumulating evidence suggests that the endolysosomal system is a novel intracellular Ca(2+) pool mobilized by the second messenger, nicotinic acid adenine dinucleotide phosphate (NAADP). Although lysosomes in neurons are known to proliferate in numerous neurodegenerative diseases and during the normal course of aging, little is known concerning the effect of lysosomal proliferation on Ca(2+) homeostasis. Here, we induce proliferation of lysosomes in primary cultures of rat hippocampal neurons a ...[more]