Ontology highlight
ABSTRACT:
SUBMITTER: Pereira GJ
PROVIDER: S-EPMC3151033 | biostudies-literature | 2011 Aug
REPOSITORIES: biostudies-literature
The Journal of biological chemistry 20110524 32
Nicotinic acid adenine dinucleotide phosphate (NAADP) is a potent Ca(2+)-mobilizing messenger that in many cells releases Ca(2+) from the endolysosomal system. Recent studies have shown that NAADP-induced Ca(2+) mobilization is mediated by the two-pore channels (TPCs). Whether NAADP acts as a messenger in astrocytes is unclear, and downstream functional consequences have yet to be defined. Here, we show that intracellular delivery of NAADP evokes Ca(2+) signals from acidic organelles in rat astr ...[more]