Association of genetic ancestry with preterm delivery and related traits among African American mothers.
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ABSTRACT: Objective
In the United States, the rate of preterm delivery (PTD) is higher in African Americans (17.8%) than non-Hispanic whites (11.5%). Such disparity cannot be fully explained by differences in socioenvironmental factors.Study design
We genotyped 812 mothers in a case-control PTD study at Boston Medical Center who self-reported their ethnicity as "black." Regression analysis and Wilcoxon rank-sum test were applied to evaluate ancestral distribution and the association between genetic ancestry and PTD-related traits, as well as the potential confounding effect of population stratification.Results
The estimated African ancestral proportion was 0.90 +/- 0.13. We found significant associations of ancestral proportion with PTD as a whole and PTD subgrouped by the presence of maternal hypertensive disorders. We did not observe significant confounding as a result of population stratification in this case-control PTD study.Conclusion
Our data underline the need for more intensive investigation of genetic admixture in African Americans to identify novel susceptibility genes of PTD.
SUBMITTER: Tsai HJ
PROVIDER: S-EPMC2859981 | biostudies-literature | 2009 Jul
REPOSITORIES: biostudies-literature
Publications
Association of genetic ancestry with preterm delivery and related traits among African American mothers.
Tsai Hui-Ju HJ Yu Yunxian Y Zhang Shanchun S Pearson Colleen C Ortiz Katherin K Xu Xiping X Bauchner Howard H Zuckerman Barry B Wang Xiaobin X
American journal of obstetrics and gynecology 20090515 1
<h4>Objective</h4>In the United States, the rate of preterm delivery (PTD) is higher in African Americans (17.8%) than non-Hispanic whites (11.5%). Such disparity cannot be fully explained by differences in socioenvironmental factors.<h4>Study design</h4>We genotyped 812 mothers in a case-control PTD study at Boston Medical Center who self-reported their ethnicity as "black." Regression analysis and Wilcoxon rank-sum test were applied to evaluate ancestral distribution and the association betwee ...[more]
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