Genetic ancestry and prostate cancer susceptibility SNPs in Puerto Rican and African American men.
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ABSTRACT:
SUBMITTER: Irizarry-Ramirez M
PROVIDER: S-EPMC5495141 | biostudies-literature | 2017 Jul
REPOSITORIES: biostudies-literature
Publications
Genetic ancestry and prostate cancer susceptibility SNPs in Puerto Rican and African American men.
Irizarry-Ramírez Margarita M Kittles Rick A RA Wang Xuemei X Salgado-Montilla Jeannette J Nogueras-González Graciela M GM Sánchez-Ortiz Ricardo R Guerrios Lourdes L Rivera Keila K Shah Ebony E Prokhorova Ina I Roberson Pamela P Troncoso Patricia P Pettaway Curtis A CA
The Prostate 20170524 10
<h4>Background</h4>The Puerto Rican (PR) population is a racially admixed population that has a high prostate cancer (PCa) mortality rate. We hypothesized in this pilot study that West African Ancestry (WAA) was associated with PCa in this heterogeneous (PR) population.<h4>Methods</h4>A case/case and case/control study was performed. Controls, 207 African American (AA) and 133 PR were defined as men with no PCa, a serum PSA < 2.5 ng/mL and a negative rectal examination. Cases were patients with ...[more]
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