Ontology highlight
ABSTRACT:
SUBMITTER: Gaitonde S
PROVIDER: S-EPMC2860277 | biostudies-literature | 2009 Apr
REPOSITORIES: biostudies-literature
Gaitonde Supriya S De Surya K SK Tcherpakov Marianna M Dewing Antimone A Yuan Hongbin H Riel-Mehan Megan M Krajewski Stan S Robertson Gavin G Pellecchia Maurizio M Ronai Ze'ev Z
Pigment cell & melanoma research 20090117 2
The AKT/PKB pathway plays a central role in tumor development and progression and is often up-regulated in different tumor types, including melanomas. We have recently reported on the in silico approach to identify putative inhibitors for AKT/PKB. Of the reported hits, we selected BI-69A11, a compound which was shown to inhibit AKT activity in in vitro kinase assays. Analysis of BI-69A11 was performed in melanoma cells, a tumor type that commonly exhibits up-regulation of AKT. Treatment of the U ...[more]