Ontology highlight
ABSTRACT:
SUBMITTER: Hwang JY
PROVIDER: S-EPMC2860454 | biostudies-literature | 2009 Mar
REPOSITORIES: biostudies-literature
Hwang Ji-yeon JY Duncan R Scott RS Madry Christian C Singh Meharvan M Koulen Peter P
Cell calcium 20081209 3
Progesterone (P4) is a steroid hormone that plays multiple roles in the central nervous system (CNS) including promoting neuroprotection. However, the precise mechanisms involved in its neuroprotective effects are still unknown. Given that the regulation of the intracellular calcium (Ca(2+)) concentration is critical for cell survival, we determined if inositol 1, 4, 5-trisphosphate receptors (IP(3)Rs) are relevant targets of P4. Using primary hippocampal neurons, we tested the hypothesis that P ...[more]