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Mechanisms and inhibition of HIV integration.

ABSTRACT: HIV integrase is required for viral replication and a rationale target for antiretroviral therapies. Integrase inhibitors are potentially complementary to current treatments. This review focuses on the mechanisms of HIV integration. The roles of viral and cellular co-factors during pre-integration complex (PIC) formation and integration are reviewed. The biochemical mechanisms of integration, integrase structures and approaches to inhibit integration are described.

SUBMITTER: Marchand C

PROVIDER: S-EPMC2860614 | biostudies-literature | 2006 Jul

REPOSITORIES: biostudies-literature

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Mechanisms and inhibition of HIV integration.

Marchand Christophe C Johnson Allison A AA Semenova Elena E Pommier Yves Y

Drug discovery today. Disease mechanisms 20060701 2

HIV integrase is required for viral replication and a rationale target for antiretroviral therapies. Integrase inhibitors are potentially complementary to current treatments. This review focuses on the mechanisms of HIV integration. The roles of viral and cellular co-factors during pre-integration complex (PIC) formation and integration are reviewed. The biochemical mechanisms of integration, integrase structures and approaches to inhibit integration are described. ...[more]

PMID: 20431697

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