NF-kappaB1 contributes to T cell-mediated control of Toxoplasma gondii in the CNS.
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ABSTRACT:
SUBMITTER: Harris TH
PROVIDER: S-EPMC2860689 | biostudies-literature | 2010 May
REPOSITORIES: biostudies-literature
Publications
NF-kappaB1 contributes to T cell-mediated control of Toxoplasma gondii in the CNS.
Harris Tajie H TH Wilson Emma H EH Tait Elia D ED Buckley Marie M Shapira Sagi S Caamano Jorge J Artis David D Hunter Christopher A CA
Journal of neuroimmunology 20100213 1-2
In this study, the role of NF-kappaB1 was examined during toxoplasmosis. While wildtype BALB/c mice generated protective responses, NF-kappaB1(-/-) mice developed Toxoplasmic encephalitis, characterized by increased parasite burden and necrosis in the brain. Susceptibility was primarily associated with a local decrease in the number of CD8(+) T cells and IFN-gamma production, while accessory cell function appeared intact in NF-kappaB1(-/-) mice. Consistent with these findings, T cell transfer st ...[more]
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