Ontology highlight
ABSTRACT:
SUBMITTER: Kuramochi-Miyagawa S
PROVIDER: S-EPMC2861188 | biostudies-literature | 2010 May
REPOSITORIES: biostudies-literature
Kuramochi-Miyagawa Satomi S Watanabe Toshiaki T Gotoh Kengo K Takamatsu Kana K Chuma Shinichiro S Kojima-Kita Kanako K Shiromoto Yusuke Y Asada Noriko N Toyoda Atsushi A Fujiyama Asao A Totoki Yasushi Y Shibata Tatsuhiro T Kimura Tohru T Nakatsuji Norio N Noce Toshiaki T Sasaki Hiroyuki H Nakano Toru T
Genes & development 20100501 9
VASA is an evolutionarily conserved RNA helicase essential for germ cell development. The mouse PIWI family proteins MILI and MIWI2 are involved in production of Piwi-interacting RNAs (piRNAs) in fetal male germ cells through a ping-pong amplification cycle. Expression of retrotransposons is elevated in MILI- and MIWI2-deficient male germ cells due to defective de novo DNA methylation, which is presumably caused by impaired piRNA expression. Here, we report that essentially the same abnormalitie ...[more]