Absence of evidence for MHC-dependent mate selection within HapMap populations.
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ABSTRACT:
SUBMITTER: Derti A
PROVIDER: S-EPMC2861700 | biostudies-literature | 2010 Apr
REPOSITORIES: biostudies-literature
Publications
Absence of evidence for MHC-dependent mate selection within HapMap populations.
Derti Adnan A Cenik Can C Kraft Peter P Roth Frederick P FP
PLoS genetics 20100429 4
The major histocompatibility complex (MHC) of immunity genes has been reported to influence mate choice in vertebrates, and a recent study presented genetic evidence for this effect in humans. Specifically, greater dissimilarity at the MHC locus was reported for European-American mates (parents in HapMap Phase 2 trios) than for non-mates. Here we show that the results depend on a few extreme data points, are not robust to conservative changes in the analysis procedure, and cannot be reproduced i ...[more]
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