Ontology highlight
ABSTRACT:
SUBMITTER: Aweda TA
PROVIDER: S-EPMC2862285 | biostudies-literature | 2010 Apr
REPOSITORIES: biostudies-literature
Aweda Tolulope A TA Beck Heather E HE Wu Anna M AM Wei Liu H LH Weber Wolfgang A WA Meares Claude F CF
Bioconjugate chemistry 20100401 4
Probe-capture systems based on proteins and synthetic ligands have become important for new analytical and imaging applications. We have used kinetic measurements of luminescence and measurements of binding by isothermal calorimetry to determine essential rate and equilibrium constants for a system that permanently captures modified DOTA chelates for positron imaging. We used that information along with previous results to quantitatively characterize the behavior of this system in vitro and in v ...[more]