Ontology highlight
ABSTRACT:
SUBMITTER: Halaas O
PROVIDER: S-EPMC2862295 | biostudies-literature | 2010 Mar
REPOSITORIES: biostudies-literature
Halaas Oyvind O Steigedal Magnus M Haug Markus M Awuh Jane A JA Ryan Liv L Brech Andreas A Sato Shintaro S Husebye Harald H Cangelosi Gerard A GA Akira Shizuo S Strong Roland K RK Espevik Terje T Flo Trude H TH
The Journal of infectious diseases 20100301 5
Iron is an essential nutrient for microbes, and many pathogenic bacteria depend on siderophores to obtain iron. The mammalian innate immunity protein lipocalin 2 (Lcn2; also known as neutrophil gelatinase-associated lipocalin, 24p3, or siderocalin) binds the siderophore carboxymycobactin, an essential component of the iron acquisition apparatus of mycobacteria. Here we show that Lcn2 suppressed growth of Mycobacterium avium in culture, and M. avium induced Lcn2 production from mouse macrophages. ...[more]