Ontology highlight
ABSTRACT:
SUBMITTER: Slaets H
PROVIDER: S-EPMC2862528 | biostudies-literature | 2010 Apr
REPOSITORIES: biostudies-literature
Slaets Helena H Hendriks Jerome J A JJ Van den Haute Chris C Coun Frea F Baekelandt Veerle V Stinissen Piet P Hellings Niels N
Molecular therapy : the journal of the American Society of Gene Therapy 20100112 4
Multiple sclerosis (MS) is a demyelinating disease of the central nervous system (CNS) with an inflammatory and a neurodegenerative component. The neuropoietic cytokine leukemia inhibitory factor (LIF) is expressed in MS lesions, but its effect on lesion development is far from understood. LIF is an interesting candidate for MS therapy, as it has neuroprotective properties and may also promote the survival of myelinating oligodendrocytes (OLGs). However, therapeutic administration of LIF is comp ...[more]