Membrane lipids influence protein complex assembly-disassembly.

ABSTRACT: Approximately 11% smaller t-/v-SNARE ring complexes are generated using 50 nm cholesterol-associated vesicles as opposed to vesicles containing L-alpha-lysophosphatidylcholine (LPC), as observed using atomic force microscopy. Circular dichroism spectroscopy demonstrated that in the presence of LPC as opposed to cholesterol, N-ethylmaleimide-sensitive factor + adenosine triphosphate induces disassembly of beta-sheet structures but not the alpha-helical contents within the t-/v-SNARE complex.

SUBMITTER: Shin L 

PROVIDER: S-EPMC2862647 | biostudies-literature | 2010 Apr

REPOSITORIES: biostudies-literature