Ontology highlight
ABSTRACT:
SUBMITTER: Sanchez I
PROVIDER: S-EPMC5079433 | biostudies-literature | 2016 Jun
REPOSITORIES: biostudies-literature
Sánchez Irma I Dynlacht Brian David BD
Nature cell biology 20160601 7
The primary cilium is an antenna-like, immotile organelle present on most types of mammalian cells, which interprets extracellular signals that regulate growth and development. Although once considered a vestigial organelle, the primary cilium is now the focus of considerable interest. We now know that ciliary defects lead to a panoply of human diseases, termed ciliopathies, and the loss of this organelle may be an early signature event during oncogenic transformation. Ciliopathies include numer ...[more]