Ontology highlight
ABSTRACT:
SUBMITTER: Kerr N
PROVIDER: S-EPMC2862884 | biostudies-literature | 2010 Jun
REPOSITORIES: biostudies-literature
Kerr Niall N Pintzas Alexander A Holmes Fiona F Hobson Sally-Ann SA Pope Robert R Wallace Mark M Wasylyk Christine C Wasylyk Bohdan B Wynick David D
Molecular and cellular neurosciences 20100318 2
ELK transcription factors are known to be expressed in a number of regions in the nervous system. We show by RT-PCR that the previously described Elk1, Elk3/Elk3b/Elk3c and Elk4 mRNAs are expressed in adult dorsal root ganglia (DRG), together with the novel alternatively spliced isoforms Elk1b, Elk3d and Elk4c/Elk4d/Elk4e. These isoforms are also expressed in brain, heart, kidney and testis. In contrast to Elk3 protein, the novel Elk3d isoform is cytoplasmic, fails to bind ETS binding sites and ...[more]