Ontology highlight
ABSTRACT:
SUBMITTER: Repapi E
PROVIDER: S-EPMC2862965 | biostudies-literature | 2010 Jan
REPOSITORIES: biostudies-literature
Repapi Emmanouela E Sayers Ian I Wain Louise V LV Burton Paul R PR Johnson Toby T Obeidat Ma'en M Zhao Jing Hua JH Ramasamy Adaikalavan A Zhai Guangju G Vitart Veronique V Huffman Jennifer E JE Igl Wilmar W Albrecht Eva E Deloukas Panos P Henderson John J Granell Raquel R McArdle Wendy L WL Rudnicka Alicja R AR Barroso Inês I Loos Ruth J F RJ Wareham Nicholas J NJ Mustelin Linda L Rantanen Taina T Surakka Ida I Imboden Medea M Wichmann H Erich HE Grkovic Ivica I Jankovic Stipan S Zgaga Lina L Hartikainen Anna-Liisa AL Peltonen Leena L Gyllensten Ulf U Johansson Asa A Zaboli Ghazal G Campbell Harry H Wild Sarah H SH Wilson James F JF Gläser Sven S Homuth Georg G Völzke Henry H Mangino Massimo M Soranzo Nicole N Spector Tim D TD Polasek Ozren O Rudan Igor I Wright Alan F AF Heliövaara Markku M Ripatti Samuli S Pouta Anneli A Naluai Asa Torinsson AT Olin Anna-Carin AC Torén Kjell K Cooper Matthew N MN James Alan L AL Palmer Lyle J LJ Hingorani Aroon D AD Wannamethee S Goya SG Whincup Peter H PH Smith George Davey GD Ebrahim Shah S McKeever Tricia M TM Pavord Ian D ID MacLeod Andrew K AK Morris Andrew D AD Porteous David J DJ Cooper Cyrus C Dennison Elaine E Shaheen Seif S Karrasch Stefan S Schnabel Eva E Schulz Holger H Grallert Harald H Bouatia-Naji Nabila N Delplanque Jérôme J Froguel Philippe P Blakey John D JD Britton John R JR Morris Richard W RW Holloway John W JW Lawlor Debbie A DA Hui Jennie J Nyberg Fredrik F Jarvelin Marjo-Riitta MR Jackson Cathy C Kähönen Mika M Kaprio Jaakko J Probst-Hensch Nicole M NM Koch Beate B Hayward Caroline C Evans David M DM Elliott Paul P Strachan David P DP Hall Ian P IP Tobin Martin D MD
Nature genetics 20091213 1
Pulmonary function measures are heritable traits that predict morbidity and mortality and define chronic obstructive pulmonary disease (COPD). We tested genome-wide association with forced expiratory volume in 1 s (FEV(1)) and the ratio of FEV(1) to forced vital capacity (FVC) in the SpiroMeta consortium (n = 20,288 individuals of European ancestry). We conducted a meta-analysis of top signals with data from direct genotyping (n < or = 32,184 additional individuals) and in silico summary associa ...[more]