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Genome-wide association study identifies five susceptibility loci for glioma.

ABSTRACT: To identify risk variants for glioma, we conducted a meta-analysis of two genome-wide association studies by genotyping 550K tagging SNPs in a total of 1,878 cases and 3,670 controls, with validation in three additional independent series totaling 2,545 cases and 2,953 controls. We identified five risk loci for glioma at 5p15.33 (rs2736100, TERT; P = 1.50 x 10(-17)), 8q24.21 (rs4295627, CCDC26; P = 2.34 x 10(-18)), 9p21.3 (rs4977756, CDKN2A-CDKN2B; P = 7.24 x 10(-15)), 20q13.33 (rs6010620, RTEL1; P = 2.52 x 10(-12)) and 11q23.3 (rs498872, PHLDB1; P = 1.07 x 10(-8)). These data show that common low-penetrance susceptibility alleles contribute to the risk of developing glioma and provide insight into disease causation of this primary brain tumor.

SUBMITTER: Shete S 

PROVIDER: S-EPMC4501476 | biostudies-literature | 2009 Aug

REPOSITORIES: biostudies-literature

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Genome-wide association study identifies five susceptibility loci for glioma.

Shete Sanjay S   Hosking Fay J FJ   Robertson Lindsay B LB   Dobbins Sara E SE   Sanson Marc M   Malmer Beatrice B   Simon Matthias M   Marie Yannick Y   Boisselier Blandine B   Delattre Jean-Yves JY   Hoang-Xuan Khe K   El Hallani Soufiane S   Idbaih Ahmed A   Zelenika Diana D   Andersson Ulrika U   Henriksson Roger R   Bergenheim A Tommy AT   Feychting Maria M   Lönn Stefan S   Ahlbom Anders A   Schramm Johannes J   Linnebank Michael M   Hemminki Kari K   Kumar Rajiv R   Hepworth Sarah J SJ   Price Amy A   Armstrong Georgina G   Liu Yanhong Y   Gu Xiangjun X   Yu Robert R   Lau Ching C   Schoemaker Minouk M   Muir Kenneth K   Swerdlow Anthony A   Lathrop Mark M   Bondy Melissa M   Houlston Richard S RS  

Nature genetics 20090705 8

To identify risk variants for glioma, we conducted a meta-analysis of two genome-wide association studies by genotyping 550K tagging SNPs in a total of 1,878 cases and 3,670 controls, with validation in three additional independent series totaling 2,545 cases and 2,953 controls. We identified five risk loci for glioma at 5p15.33 (rs2736100, TERT; P = 1.50 x 10(-17)), 8q24.21 (rs4295627, CCDC26; P = 2.34 x 10(-18)), 9p21.3 (rs4977756, CDKN2A-CDKN2B; P = 7.24 x 10(-15)), 20q13.33 (rs6010620, RTEL1  ...[more]

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