Ontology highlight
ABSTRACT:
SUBMITTER: Foster KG
PROVIDER: S-EPMC2863215 | biostudies-literature | 2010 May
REPOSITORIES: biostudies-literature
Foster Kathryn G KG Fingar Diane C DC
The Journal of biological chemistry 20100315 19
The mammalian target of rapamycin (mTOR) protein kinase responds to diverse environmental cues to control a plethora of cellular processes. mTOR forms the catalytic core of at least two distinct signaling complexes known as mTOR complexes 1 and 2. Differing sensitivities to the mTOR inhibitor rapamycin, unique partner proteins, distinct substrates, and unique cellular functions distinguish the complexes. Here, we review recent progress in our understanding of the regulation and function of mTOR ...[more]