Ontology highlight
ABSTRACT:
SUBMITTER: Wong M
PROVIDER: S-EPMC3880546 | biostudies-literature | 2013 Mar-Apr
REPOSITORIES: biostudies-literature
Biomedical journal 20130301 2
The mammalian target of rapamycin (mTOR) pathway is an essential cellular signaling pathway involved in a number of important physiological functions, including cell growth, proliferation, metabolism, protein synthesis, and autophagy. Dysregulation of the mTOR pathway has been implicated in the pathophysiology of a number of neurological diseases. Hyperactivation of the mTOR pathway, leading to increased cell growth and proliferation, has been most convincingly shown to stimulate tumor growth in ...[more]