Ontology highlight
ABSTRACT:
SUBMITTER: Adams AC
PROVIDER: S-EPMC2863226 | biostudies-literature | 2010 May
REPOSITORIES: biostudies-literature
Adams Andrew C AC Astapova Inna I Fisher Ffolliott M FM Badman Michael K MK Kurgansky Katherine E KE Flier Jeffrey S JS Hollenberg Anthony N AN Maratos-Flier Eleftheria E
The Journal of biological chemistry 20100317 19
Thyroid hormone has profound and diverse effects on liver metabolism. Here we show that tri-iodothyronine (T3) treatment in mice acutely and specifically induces hepatic expression of the metabolic regulator fibroblast growth factor 21 (FGF21). Mice treated with T3 showed a dose-dependent increase in hepatic FGF21 expression with significant induction at doses as low as 100 microg/kg. Time course studies determined that induction is seen as early as 4 h after treatment with a further increase in ...[more]