Ontology highlight
ABSTRACT:
SUBMITTER: Konig B
PROVIDER: S-EPMC2786200 | biostudies-literature | 2009
REPOSITORIES: biostudies-literature
König Bettina B Rauer Christine C Rosenbaum Susann S Brandsch Corinna C Eder Klaus K Stangl Gabriele I GI
PPAR research 20090101
PPARalpha is a lipid-activable transcription factor that mediates the adaptive response to fasting. Recent data indicate an important role of brain PPARalpha in physiological functions. However, it has not yet been shown whether PPARalpha in brain can be activated in the fasting state. Here we demonstrate that fasting of rats increased mRNA concentrations of typical PPARalpha target genes implicated in beta-oxidation of fatty acids (acyl-CoA oxidase, carnitine palmitoyltransferase-1, medium chai ...[more]