Ontology highlight
ABSTRACT:
SUBMITTER: Kleba B
PROVIDER: S-EPMC2863521 | biostudies-literature | 2010 May
REPOSITORIES: biostudies-literature
Kleba Betsy B Clark Tina R TR Lutter Erika I EI Ellison Damon W DW Hackstadt Ted T
Infection and immunity 20100301 5
Rickettsii rickettsii, the etiologic agent of Rocky Mountain spotted fever, replicates within the cytosol of infected cells and uses actin-based motility to spread inter- and intracellularly. Although the ultrastructure of the actin tail and host proteins associated with it are distinct from those of Listeria or Shigella, comparatively little is known regarding the rickettsial proteins involved in its organization. Here, we have used random transposon mutagenesis of R. rickettsii to generate a s ...[more]