Ontology highlight
ABSTRACT:
SUBMITTER: Serio AW
PROVIDER: S-EPMC2935136 | biostudies-literature | 2010 May
REPOSITORIES: biostudies-literature
Cell host & microbe 20100501 5
Many Rickettsia species are intracellular bacterial pathogens that use actin-based motility for spread during infection. However, while other bacteria assemble actin tails consisting of branched networks, Rickettsia assemble long parallel actin bundles, suggesting the use of a distinct mechanism for exploiting actin. To identify the underlying mechanisms and host factors involved in Rickettsia parkeri actin-based motility, we performed an RNAi screen targeting 115 actin cytoskeletal genes in Dro ...[more]