Ontology highlight
ABSTRACT:
SUBMITTER: Avril M
PROVIDER: S-EPMC2863527 | biostudies-literature | 2010 May
REPOSITORIES: biostudies-literature
Avril Marion M Cartwright Megan M MM Hathaway Marianne J MJ Hommel Mirja M Elliott Salenna R SR Williamson Kathryn K Narum David L DL Duffy Patrick E PE Fried Michal M Beeson James G JG Smith Joseph D JD
Infection and immunity 20100301 5
Pregnancy-associated malaria is a severe clinical syndrome associated with the sequestration of Plasmodium falciparum-infected erythrocytes in the placenta. Placental binding is mediated by VAR2CSA, a member of the large and diverse P. falciparum erythrocyte membrane 1 (PfEMP1) protein family. To better understand if conserved regions in VAR2CSA can be targeted by antibodies, we immunized rabbits with VAR2CSA-DBL1 and -DBL5 recombinant proteins produced in Pichia pastoris and developed a panel o ...[more]