Ontology highlight
ABSTRACT:
SUBMITTER: Trost BM
PROVIDER: S-EPMC2864593 | biostudies-literature | 2010 Apr
REPOSITORIES: biostudies-literature
Journal of the American Chemical Society 20100401 14
A highly enantioselective method for the catalytic addition of terminal 1,3-diynes to aldehydes was developed using our dinuclear zinc ProPhenol (1) system. Furthermore, triphenylphosphine oxide was found to interact synergistically with the catalyst to substantially enhance the chiral recognition. The generality of this catalytic transformation was demonstrated with aryl, alpha,beta-unsaturated and saturated aldehydes, of which the latter were previously limited in alkynyl zinc additions. The c ...[more]