Threading the needle: getting selenocysteine into proteins.
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ABSTRACT:
SUBMITTER: Donovan J
PROVIDER: S-EPMC2864665 | biostudies-literature | 2010 Apr
REPOSITORIES: biostudies-literature
Publications
Threading the needle: getting selenocysteine into proteins.
Donovan Jesse J Copeland Paul R PR
Antioxidants & redox signaling 20100401 7
The co-translational incorporation of selenocysteine (Sec) requires that UGA be recognized as a sense rather than a nonsense codon. This is accomplished by the concerted action of a Sec insertion sequence (SECIS) element, SECIS binding protein 2, and a ternary complex of the Sec specific elongation factor, Sec-tRNA(Sec), and GTP. The mechanism by which they alter the canonical protein synthesis reaction has been elusive. Here we present an overview of the mechanistic perspective on Sec incorpora ...[more]
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