Ontology highlight
ABSTRACT:
SUBMITTER: Fu X
PROVIDER: S-EPMC6103685 | biostudies-literature | 2018
REPOSITORIES: biostudies-literature
Fu Xian X Söll Dieter D Sevostyanova Anastasia A
RNA biology 20180312 4-5
Selenocysteine (Sec), a rare genetically encoded amino acid with unusual chemical properties, is of great interest for protein engineering. Sec is synthesized on its cognate tRNA (tRNA<sup>Sec</sup>) by the concerted action of several enzymes. While all other aminoacyl-tRNAs are delivered to the ribosome by the elongation factor Tu (EF-Tu), Sec-tRNA<sup>Sec</sup> requires a dedicated factor, SelB. Incorporation of Sec into protein requires recoding of the stop codon UGA aided by a specific mRNA ...[more]