Ontology highlight
ABSTRACT:
SUBMITTER: Zoltowski BD
PROVIDER: S-EPMC2865183 | biostudies-literature | 2009 Nov
REPOSITORIES: biostudies-literature
Zoltowski Brian D BD Vaccaro Brian B Crane Brian R BR
Nature chemical biology 20090830 11
Phototropin-like LOV domains form a cysteinyl-flavin adduct in response to blue light but show considerable variation in output signal and the lifetime of the photo-adduct signaling state. Mechanistic studies of the slow-cycling fungal LOV photoreceptor Vivid (VVD) reveal the importance of reactive cysteine conformation, flavin electronic environment and solvent accessibility for adduct scission and thermal reversion. Proton inventory, pH effects, base catalysis and structural studies implicate ...[more]