Ontology highlight
ABSTRACT:
SUBMITTER: Shiwarski DJ
PROVIDER: S-EPMC6589700 | biostudies-literature | 2019 Mar
REPOSITORIES: biostudies-literature
Shiwarski Daniel J DJ Crilly Stephanie E SE Dates Andrew A Puthenveedu Manojkumar A MA
Molecular biology of the cell 20190102 5
The delta opioid receptor (DOR), a physiologically relevant prototype for G protein-coupled receptors, is retained in intracellular compartments in neuronal cells. This retention is mediated by a nerve growth factor (NGF)-regulated checkpoint that delays the export of DOR from the trans-Golgi network. How DOR is selectively retained in the Golgi, in the midst of dynamic membrane transport and cargo export, is a fundamental unanswered question. Here we address this by investigating sequence eleme ...[more]