Ontology highlight
ABSTRACT:
SUBMITTER: Pfaff SJ
PROVIDER: S-EPMC2865338 | biostudies-literature | 2010 May
REPOSITORIES: biostudies-literature
Pfaff Samuel J SJ Fletterick Robert J RJ
The Journal of biological chemistry 20100324 20
The glucocorticoid receptor initiates the cellular response to glucocorticoid steroid hormones in vertebrates. Co-regulator proteins dock to the receptor in response to hormone binding and potentiate the transcriptional activity of the receptor by modifying DNA and recruiting essential transcription factors like RNA polymerase II. Hormones and co-regulators bind at distinct sites in the ligand binding domain yet function cooperatively to mediate transcriptional control. This study reveals and qu ...[more]