Ontology highlight
ABSTRACT:
SUBMITTER: Watson LC
PROVIDER: S-EPMC3702670 | biostudies-literature | 2013 Jul
REPOSITORIES: biostudies-literature
Watson Lisa C LC Kuchenbecker Kristopher M KM Schiller Benjamin J BJ Gross John D JD Pufall Miles A MA Yamamoto Keith R KR
Nature structural & molecular biology 20130602 7
Glucocorticoid receptor (GR) binds to genomic response elements and regulates gene transcription with cell and gene specificity. Within a response element, the precise sequence to which the receptor binds has been implicated in directing its structure and activity. Here, we use NMR chemical-shift difference mapping to show that nonspecific interactions with bases at particular positions in the binding sequence, such as those of the 'spacer', affect the conformation of distinct regions of the rat ...[more]