Ontology highlight
ABSTRACT:
SUBMITTER: Yamanaka T
PROVIDER: S-EPMC2865370 | biostudies-literature | 2010 Jun
REPOSITORIES: biostudies-literature
Yamanaka Tomoyuki T Tosaki Asako A Miyazaki Haruko H Kurosawa Masaru M Furukawa Yoshiaki Y Yamada Mizuki M Nukina Nobuyuki N
Human molecular genetics 20100225 11
In polyglutamine diseases including Huntington's disease (HD), mutant proteins containing expanded polyglutamine stretches form nuclear aggregates in neurons. Although analysis of their disease models suggested a significance of transcriptional dysregulation in these diseases, how it mediates the specific neuronal cell dysfunction remains obscure. Here we performed a comprehensive analysis of altered DNA binding of multiple transcription factors using R6/2 HD model mice brains that express an N- ...[more]