Ontology highlight
ABSTRACT:
SUBMITTER: Smith J
PROVIDER: S-EPMC2866106 | biostudies-literature | 2010 Feb
REPOSITORIES: biostudies-literature
Smith Jason J Stewart Benjamin J BJ Glaysher Sharon S Peregrin Katharine K Knight Louise A LA Weber David J DJ Cree Ian A IA
Anti-cancer drugs 20100201 2
Pentamidine is a small molecule inhibitor of the Ca(+)-binding protein S100B and disrupts the S100B-p53 protein-protein interaction; this is thought to restore wild-type p53 tumour suppressor function in melanoma. Additional anticancer effects may be the result of inhibition of regenerating liver family phosphatases. In this study, we have used a standardized ATP-tumour chemosensitivity assay to investigate the effect of pentamidine on cells derived from 18 skin melanoma samples and one uveal me ...[more]