Ontology highlight
ABSTRACT:
SUBMITTER: Lee MW
PROVIDER: S-EPMC3687591 | biostudies-literature | 2013
REPOSITORIES: biostudies-literature
Lee Myoung Woo MW Kim Dae Seong DS Ryu Somi S Jang In Keun IK Kim Hye Jin HJ Yang Jin Mo JM Lee Doo-Hoon DH Lee Soo Hyun SH Son Meong Hi MH Cheuh Hee Won HW Jung Hye Lim HL Yoo Keon Hee KH Sung Ki Woong KW Koo Hong Hoe HH
BioMed research international 20130604
A microarray analysis was performed to investigate whether ex vivo culture conditions affect the characteristics of MSCs. Gene expression profiles were mainly influenced by the level of cell confluence rather than initial seeding density. The analysis showed that 276 genes were upregulated and 230 genes downregulated in MSCs harvested at ~90% versus ~50% confluence (P < 0.05, FC > 2). The genes that were highly expressed in MSCs largely corresponded to chemotaxis, inflammation, and immune respon ...[more]