Ontology highlight
ABSTRACT:
SUBMITTER: Dittmer DP
PROVIDER: S-EPMC2866115 | biostudies-literature | 2008 Nov
REPOSITORIES: biostudies-literature
Dittmer Dirk P DP Hilscher Chelsey J CJ Gulley Margaret L ML Yang Eric V EV Chen Min M Glaser Ronald R
International journal of cancer 20081101 9
Epstein-Barr virus (EBV) is the prototypical example for episomal persistence of genetic information. Yet, little is known about how this viral episome is lost. Episome loss occurs naturally in nasopharyngeal carcinoma (NPC) upon explantation into culture. Using whole-genome profiling, we found evidence for 2 different pathways of episome loss: (i) rapid loss of the entire episome or (ii) successive mutation/deletion of the episome until at least 1 essential cis-element is destroyed. This second ...[more]