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Epstein-Barr Virus Mediated Signaling in Nasopharyngeal Carcinoma Carcinogenesis.


ABSTRACT: Nasopharyngeal carcinoma (NPC) is one of the most common tumors occurring in China and Southeast Asia. Etiology of NPC seems to be complex and involves many determinants, one of which is Epstein-Barr virus (EBV) infection. Although evidence demonstrates that EBV infection plays a key role in NPC carcinogenesis, the exact relationship between EBV and dysregulation of signaling pathways in NPC needs to be clarified. This review focuses on the interplay between EBV and NPC cells and the corresponding signaling pathways, which are modulated by EBV oncoproteins and non-coding RNAs. These altered signaling pathways could be critical for the initiation and progression of NPC.

SUBMITTER: Richardo T 

PROVIDER: S-EPMC7565514 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature

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Epstein-Barr Virus Mediated Signaling in Nasopharyngeal Carcinoma Carcinogenesis.

Richardo Timmy T   Prattapong Pongphol P   Ngernsombat Chawalit C   Wisetyaningsih Nurulfitri N   Iizasa Hisashi H   Yoshiyama Hironori H   Janvilisri Tavan T  

Cancers 20200828 9


Nasopharyngeal carcinoma (NPC) is one of the most common tumors occurring in China and Southeast Asia. Etiology of NPC seems to be complex and involves many determinants, one of which is Epstein-Barr virus (EBV) infection. Although evidence demonstrates that EBV infection plays a key role in NPC carcinogenesis, the exact relationship between EBV and dysregulation of signaling pathways in NPC needs to be clarified. This review focuses on the interplay between EBV and NPC cells and the correspondi  ...[more]

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