Ontology highlight
ABSTRACT:
SUBMITTER: Burkitt W
PROVIDER: S-EPMC2867022 | biostudies-literature | 2010 Apr
REPOSITORIES: biostudies-literature
Burkitt William W Domann Paula P O'Connor Gavin G
Protein science : a publication of the Protein Society 20100401 4
Oxidation of methionine residues in biopharmaceuticals is a common and often unwanted modification that frequently occurs during their manufacture and storage. It often results in a lack of stability and biological function of the product, necessitating continuous testing for the modification throughout the product shelf life. A major class of biopharmaceutical products are monoclonal antibodies (mAbs), however, techniques for their detailed structural analysis have until recently been limited. ...[more]