Ontology highlight
ABSTRACT:
SUBMITTER: Swartling FJ
PROVIDER: S-EPMC2867210 | biostudies-literature | 2010 May
REPOSITORIES: biostudies-literature
Swartling Fredrik J FJ Grimmer Matthew R MR Hackett Christopher S CS Northcott Paul A PA Fan Qi-Wen QW Goldenberg David D DD Lau Jasmine J Masic Selma S Nguyen Kim K Yakovenko Slava S Zhe Xiao-Ning XN Gilmer Heather C Flynn HC Collins Rodney R Nagaoka Mai M Phillips Joanna J JJ Jenkins Robert B RB Tihan Tarik T Vandenberg Scott R SR James C David CD Tanaka Kohichi K Taylor Michael D MD Weiss William A WA Chesler Louis L
Genes & development 20100501 10
Medulloblastoma (MB) is the most common malignant brain tumor of childhood. Sonic Hedgehog (SHH) signaling drives a minority of MB, correlating with desmoplastic pathology and favorable outcome. The majority, however, arises independently of SHH and displays classic or large cell anaplastic (LCA) pathology and poor prognosis. To identify common signaling abnormalities, we profiled mRNA, demonstrating misexpression of MYCN in the majority of human MB and negligible expression in normal cerebella. ...[more]