Ontology highlight
ABSTRACT:
SUBMITTER: Zhao TJ
PROVIDER: S-EPMC2867684 | biostudies-literature | 2010 Apr
REPOSITORIES: biostudies-literature
Zhao Tong-Jin TJ Liang Guosheng G Li Robert Lin RL Xie Xuefen X Sleeman Mark W MW Murphy Andrew J AJ Valenzuela David M DM Yancopoulos George D GD Goldstein Joseph L JL Brown Michael S MS
Proceedings of the National Academy of Sciences of the United States of America 20100315 16
Ghrelin O-acyltransferase (GOAT) attaches octanoate to proghrelin, which is processed to ghrelin, an octanoylated peptide hormone that stimulates release of growth hormone (GH) from pituitary cells. Elimination of the gene encoding ghrelin or its receptor produces only mild phenotypes in mice. Thus, the essential function of ghrelin is obscure. Here, we eliminate the Goat gene in mice, thereby eliminating all octanoylated ghrelin from blood. On normal or high fat diets, Goat(-/-) mice grew and m ...[more]