Ontology highlight
ABSTRACT:
SUBMITTER: Liu C
PROVIDER: S-EPMC2867837 | biostudies-literature | 2010 May
REPOSITORIES: biostudies-literature
Liu Changmei C Teng Zhao-Qian ZQ Santistevan Nicholas J NJ Szulwach Keith E KE Guo Weixiang W Jin Peng P Zhao Xinyu X
Cell stem cell 20100501 5
Methyl-CpG binding protein 1 (MBD1) regulates gene expression via a DNA methylation-mediated epigenetic mechanism. We have previously demonstrated that MBD1 deficiency impairs adult neural stem/progenitor cell (aNSC) differentiation and neurogenesis, but the underlying mechanism was unclear. Here, we show that MBD1 regulates the expression of several microRNAs in aNSCs and, specifically, that miR-184 is directly repressed by MBD1. High levels of miR-184 promoted proliferation but inhibited diffe ...[more]